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Synthesis and biological evaluation of novel 1,2,3-triazole hybrids of cabotegravir: identification of potent antitumor activity against lung cancer

In pursuit of discovering novel anticancer agents, we designed and synthesized a series of novel 1,2,3-triazole hybrids based on cabotegravir analogues. These compounds were subjected to initial biological evaluations to assess their anticancer activities against non-small-cell lung cancer (NSCLC)....

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Principais autores: Yajie Guo, Dan Sang, Bin Guo, Dan Wang, Xinyue Xu, Huili Wang, Cuilan Hou, Longfei Mao, Fang Li, Sanqiang Li
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-09-01
coleção:Frontiers in Pharmacology
Assuntos:
1,2,3-triazoles
cabotegravir
anticancer
lung cancer
apoptosis
ROS
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2023.1265245/full
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