In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Cancer‐associated fibroblasts (CAFs) are sought after as potential therapeutic targets due to their pro‐ and antitumorigenic functions, which are attributed to specializations in CAF subtypes. A precise targeting of specific subtypes would be required to design therapies that effectively modulate CA...

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Detalhes bibliográficos

Principais autores:	Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-05-01
coleção:	Molecular Oncology
Assuntos:	CAF heterogeneity cancer‐associated fibroblast pancreatic tumor Perturb‐seq single‐cell transcriptomics tumor microenvironment
Acesso em linha:	https://doi.org/10.1002/1878-0261.70153
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