In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Cancer‐associated fibroblasts (CAFs) are sought after as potential therapeutic targets due to their pro‐ and antitumorigenic functions, which are attributed to specializations in CAF subtypes. A precise targeting of specific subtypes would be required to design therapies that effectively modulate CA...

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Autors principals:	Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2026-05-01
Col·lecció:	Molecular Oncology
Matèries:	CAF heterogeneity cancer‐associated fibroblast pancreatic tumor Perturb‐seq single‐cell transcriptomics tumor microenvironment
Accés en línia:	https://doi.org/10.1002/1878-0261.70153
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