APOE4 drives widespread changes to the hepatic proteome and alters metabolic function

Summary: Apolipoprotein E (APOE) is essential for lipid homeostasis and has been extensively studied in Alzheimer’s disease (AD). Individuals carrying an APOE4 allele have an increased risk of AD and exhibit deficits in energy metabolism, including glucose utilization and mitochondrial dysfunction....

Popoln opis

Bibliografske podrobnosti

Principais autores:	Colton R. Lysaker, Chelsea N. Johnson, Vivien Csikos, Edziu Franczak, Ashley L. Tetlow, Maggie Benson, John P. Thyfault, Paige C. Geiger, Jill K. Morris, Heather M. Wilkins
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2026-03-01
Serija:	iScience
Teme:	Biochemistry Human metabolism Proteomics
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2589004226004104
Oznake:	Označite Brez oznak, prvi označite!