APOE4 drives widespread changes to the hepatic proteome and alters metabolic function
Summary: Apolipoprotein E (APOE) is essential for lipid homeostasis and has been extensively studied in Alzheimer’s disease (AD). Individuals carrying an APOE4 allele have an increased risk of AD and exhibit deficits in energy metabolism, including glucose utilization and mitochondrial dysfunction....
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| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2026-03-01
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| coleção: | iScience |
| Assuntos: | |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2589004226004104 |
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