APOE4 Drives Sex‐ and Diet‐Dependent Effects on AD‐Like Pathology, Cognition, and Mitochondrial Function

ABSTRACT Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), yet it's unclear how this allele promotes disease. While factors like diet and sex may modify AD susceptibility in APOE4 carriers, the interaction between these factors is poorly understood. Here, w...

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Detalhes bibliográficos

Principais autores:	Chelsea N. Johnson, Colton R. Lysaker, Xin Cao, Vivien Csikos, Frederick Boakye, Paul J. Kueck, Edziu Franczak, Paige C. Geiger, Jill K. Morris, John P. Thyfault, Heather M. Wilkins
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-05-01
coleção:	FASEB BioAdvances
Assuntos:	Alzheimer's disease apolipoprotein E learning memory mitochondria neurodegeneration
Acesso em linha:	https://doi.org/10.1096/fba.2026-00121
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