Pharmacological Inhibition of the PI3K/AKT/mTOR Pathway in Rheumatoid Arthritis Synoviocytes: A Systematic Review and Meta-Analysis (Preclinical)

<b>Background/Objectives</b>: Constitutive activation of the PI3K/AKT/mTOR signaling cascade underlies the aggressive phenotype of fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA); however, a quantitative synthesis of in vitro data on pathway inhibition remains lacking. This systemat...

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Detalhes bibliográficos

Principais autores:	Tatiana Bobkova, Artem Bobkov, Yang Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-08-01
Colecção:	Pharmaceuticals
Assuntos:	rheumatoid arthritis fibroblast-like synoviocytes PI3K/AKT/mTOR pathway inhibition p-AKT p-mTOR
Acesso em linha:	https://www.mdpi.com/1424-8247/18/8/1152
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