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Aged Mouse Hippocampus Exhibits Signs of Chronic Hypoxia and an Impaired HIF-Controlled Response to Acute Hypoxic Exposures

Altered hypoxia-inducible factor-alpha (HIF-α) activity may have significant consequences in the hippocampus, which mediates declarative memory, has limited vascularization, and is vulnerable to hypoxic insults. Previous studies have reported that neurovascular coupling is reduced in aged brains and...

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Principais autores: Brina Snyder, Hua-Kang Wu, Brianna Tillman, Thomas F. Floyd
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2022-01-01
Serija:Cells
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Online dostop:https://www.mdpi.com/2073-4409/11/3/423
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