Metabolic Detoxification of Glucose and 4-Hydroxynonenal in Human Neuroblastoma Cell Models

Background: Neuroblastoma (NB) progression is influenced by metabolic and redox adaptations. The polyol pathway, driven by aldose reductase (AKR1B1) and sorbitol dehydrogenase (SORD), is activated in hyperglycemic conditions, while detoxification of lipid peroxidation products such as 4-hydroxynonen...

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Bibliografiska uppgifter

Huvudupphov:	Martina Avanatti, Gemma Sardelli, Rossella Mosca, Francesco Balestri, Giovanni Signore, Francesca Felice, Antonella Del Corso, Roberta Moschini
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2026-02-01
Serie:	Antioxidants
Ämnen:	neuroblastoma hyperglycemia oxidative stress aldose reductase carbonyl reductase 1
Länkar:	https://www.mdpi.com/2076-3921/15/3/298
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