Metabolic Detoxification of Glucose and 4-Hydroxynonenal in Human Neuroblastoma Cell Models

Background: Neuroblastoma (NB) progression is influenced by metabolic and redox adaptations. The polyol pathway, driven by aldose reductase (AKR1B1) and sorbitol dehydrogenase (SORD), is activated in hyperglycemic conditions, while detoxification of lipid peroxidation products such as 4-hydroxynonen...

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Hlavní autoři:	Martina Avanatti, Gemma Sardelli, Rossella Mosca, Francesco Balestri, Giovanni Signore, Francesca Felice, Antonella Del Corso, Roberta Moschini
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2026-02-01
Edice:	Antioxidants
Témata:	neuroblastoma hyperglycemia oxidative stress aldose reductase carbonyl reductase 1
On-line přístup:	https://www.mdpi.com/2076-3921/15/3/298
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