Natural Killer Cells and Neuroblastoma: tumor recognition, escape mechanisms and possible novel immunotherapeutic approaches

Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood and arises from developing sympathetic nervous system. Most primary tumors localize in the abdomen, the adrenal gland or lumbar sympathetic ganglia. Amplification in tumor cells of MYCN, the major oncogenic driver, patients...

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Principais autores:	Cristina eBottino, Alessandra eDondero, Francesca eBellora, Lorenzo eMoretta, Franco eLocatelli, Vito ePistoia, Alessandro eMoretta, Roberta eCastriconi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2014-02-01
coleção:	Frontiers in Immunology
Assuntos:	Exosomes Neuroblastoma Chemokine receptors natural killer (NK) cells TGF-beta anti-tumor immunity
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00056/full
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