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Updated clinical and biological information from the two-stage phase II study of imatinib mesylate in subjects with relapsed/refractory neuroblastoma

Several studies support the notion that the kinase inhibitor Imatinib mesylate exerts off-target effects on cells of the immune system. After our first report of continuous daily oral administration in subjects with relapsed/refractory neuroblastoma (NB, EudraCT: 2005–005778-63), here we update the...

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Principais autores: Fabio Morandi, Loredana Amoroso, Alessandra Dondero, Roberta Castriconi, Stefano Parodi, Roberto Luksch, Fiorina Casale, Aurora Castellano, Alberto Garaventa, Alessandro Moretta, Cristina Bottino, Mirco Ponzoni, Maria Valeria Corrias
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2018-09-01
Serier:OncoImmunology
Fag:
imatinib mesylate
neuroblastoma
pharmacokinetics
cytokines
nk cells
Online adgang:http://dx.doi.org/10.1080/2162402X.2018.1468953
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