Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways

Osteoclasts with elevated bone resorption are commonly present in postmenopausal osteoporosis, and other osteolytic pathologies. Therefore, suppressing osteoclast generation and function has been the main focus of osteoporosis treatment. Betulinic acid (BA) represents a triterpenoid mainly purified...

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Detalhes bibliográficos

Principais autores:	Jiyong Wei, Yicheng Li, Qian Liu, Yanni Lan, Chengming Wei, Kun Tian, Liwei Wu, Chunbo Lin, Jiake Xu, Jinmin Zhao, Yuan Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-07-01
coleção:	Frontiers in Pharmacology
Assuntos:	betulinic acid osteoclast receptor activator of nuclear factor‐κB ligand osteoporosis MAPK
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphar.2020.01025/full
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