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Betulinic Acid Protects From Bone Loss in Ovariectomized Mice and Suppresses RANKL-Associated Osteoclastogenesis by Inhibiting the MAPK and NFATc1 Pathways

Osteoclasts with elevated bone resorption are commonly present in postmenopausal osteoporosis, and other osteolytic pathologies. Therefore, suppressing osteoclast generation and function has been the main focus of osteoporosis treatment. Betulinic acid (BA) represents a triterpenoid mainly purified...

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Bibliografiske detaljer
Principais autores: Jiyong Wei, Yicheng Li, Qian Liu, Yanni Lan, Chengming Wei, Kun Tian, Liwei Wu, Chunbo Lin, Jiake Xu, Jinmin Zhao, Yuan Yang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-07-01
Serier:Frontiers in Pharmacology
Fag:
Online adgang:https://www.frontiersin.org/article/10.3389/fphar.2020.01025/full
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