Mosaic Hemagglutinin-Based Whole Inactivated Virus Vaccines Induce Broad Protection Against Influenza B Virus Challenge in Mice

Influenza viruses undergo antigenic changes in the immuno-dominant hemagglutinin (HA) head domain, necessitating annual re-formulation of and re-vaccination with seasonal influenza virus vaccines for continuing protection. We previously synthesized mosaic HA (mHA) proteins of influenza B viruses whi...

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Bibliographic Details

Main Authors:	Yonghong Liu, Shirin Strohmeier, Irene González-Domínguez, Jessica Tan, Viviana Simon, Florian Krammer, Adolfo García-Sastre, Peter Palese, Weina Sun
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Immunology
Subjects:	influenza B virus whole inactivated virus vaccine immuno-subdominant epitopes broad protection universal influenza B vaccine
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.746447/full
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