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Mosaic Hemagglutinin-Based Whole Inactivated Virus Vaccines Induce Broad Protection Against Influenza B Virus Challenge in Mice

Influenza viruses undergo antigenic changes in the immuno-dominant hemagglutinin (HA) head domain, necessitating annual re-formulation of and re-vaccination with seasonal influenza virus vaccines for continuing protection. We previously synthesized mosaic HA (mHA) proteins of influenza B viruses whi...

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Автори: Yonghong Liu, Shirin Strohmeier, Irene González-Domínguez, Jessica Tan, Viviana Simon, Florian Krammer, Adolfo García-Sastre, Peter Palese, Weina Sun
Формат: Artigo
Мова:Inglês
Опубліковано: Frontiers Media S.A. 2021-09-01
Серія:Frontiers in Immunology
Предмети:
influenza B virus
whole inactivated virus vaccine
immuno-subdominant epitopes
broad protection
universal influenza B vaccine
Онлайн доступ:https://www.frontiersin.org/articles/10.3389/fimmu.2021.746447/full
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