Structural and functional impact of MProG48Y/ΔP168 mutations in SARS-CoV-2 main protease exhibiting resistance to potent inhibitors

Mutations in the main protease (MPro) can alter its enzymatic function and influence drug susceptibility, impacting SARS-CoV-2 maturation and propagation. In this study we examine the effects of G48Y and ΔP168 mutation/deletion, located in the substrate-binding subsites S2 and S4, on dimer stability...

Descripció completa

Dades bibliogràfiques

Autors principals:	Dipendra Bhandari, Oksana Gerlits, Stephen Keable, Leighton Coates, Annie Aniana, Rodolfo Ghirlando, Nashaat Nashed, Andrey Kovalevsky, John Louis
Format:	Artigo
Idioma:	Inglês
Publicat:	AIP Publishing LLC and ACA 2025-10-01
Col·lecció:	Structural Dynamics
Accés en línia:	https://pubs.aip.org/aca/sdy/article-pdf/12/5_Supplement/A118/20775569/a118_1_4.0000908.pdf
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!