Structural and functional impact of MProG48Y/ΔP168 mutations in SARS-CoV-2 main protease exhibiting resistance to potent inhibitors

Mutations in the main protease (MPro) can alter its enzymatic function and influence drug susceptibility, impacting SARS-CoV-2 maturation and propagation. In this study we examine the effects of G48Y and ΔP168 mutation/deletion, located in the substrate-binding subsites S2 and S4, on dimer stability...

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Autori principali:	Dipendra Bhandari, Oksana Gerlits, Stephen Keable, Leighton Coates, Annie Aniana, Rodolfo Ghirlando, Nashaat Nashed, Andrey Kovalevsky, John Louis
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	AIP Publishing LLC and ACA 2025-10-01
Serie:	Structural Dynamics
Accesso online:	https://pubs.aip.org/aca/sdy/article-pdf/12/5_Supplement/A118/20775569/a118_1_4.0000908.pdf
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