Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors
Abstract A critical step for SARS-CoV-2 assembly and maturation involves the autoactivation of the main protease (MProWT) from precursor polyproteins. Upon expression, a model precursor of MProWT mediates its own release at its termini rapidly to yield a mature dimer. A construct with an E290A mutat...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2023-11-01
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| coleção: | Communications Biology |
| Acesso em linha: | https://doi.org/10.1038/s42003-023-05469-8 |
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