Construction of EpCAM overexpression and knockdown vectors and their implications in colorectal cancer research

BackgroundThe functional characterization of Epithelial Cell Adhesion Molecule (EpCAM) in colorectal cancer (CRC) progression has been constrained by methodological limitations, particularly the potential for truncated protein isoforms to confound traditional genetic knockout approaches. This study...

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Autores principales:	Bingping Wang, Jinkai Duan, Jie Zhou, Hulin Ma, Meng Ren, Liangquan Chen, Rina Su, Hao Zhang, Shuang Zhang, Yanwei Gao
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2025-11-01
Colección:	Frontiers in Genome Editing
Materias:	epithelial cell adhesion molecule CRISPR/Cas9 colorectal cancer translational models metastasis
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fgeed.2025.1679698/full
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