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Construction of EpCAM overexpression and knockdown vectors and their implications in colorectal cancer research

BackgroundThe functional characterization of Epithelial Cell Adhesion Molecule (EpCAM) in colorectal cancer (CRC) progression has been constrained by methodological limitations, particularly the potential for truncated protein isoforms to confound traditional genetic knockout approaches. This study...

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Kaydedildi:
Asıl Yazarlar: Bingping Wang, Jinkai Duan, Jie Zhou, Hulin Ma, Meng Ren, Liangquan Chen, Rina Su, Hao Zhang, Shuang Zhang, Yanwei Gao
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2025-11-01
Seri Bilgileri:Frontiers in Genome Editing
Konular:
epithelial cell adhesion molecule
CRISPR/Cas9
colorectal cancer
translational models
metastasis
Online Erişim:https://www.frontiersin.org/articles/10.3389/fgeed.2025.1679698/full
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