Construction of EpCAM overexpression and knockdown vectors and their implications in colorectal cancer research

BackgroundThe functional characterization of Epithelial Cell Adhesion Molecule (EpCAM) in colorectal cancer (CRC) progression has been constrained by methodological limitations, particularly the potential for truncated protein isoforms to confound traditional genetic knockout approaches. This study...

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Autors principals:	Bingping Wang, Jinkai Duan, Jie Zhou, Hulin Ma, Meng Ren, Liangquan Chen, Rina Su, Hao Zhang, Shuang Zhang, Yanwei Gao
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-11-01
Col·lecció:	Frontiers in Genome Editing
Matèries:	epithelial cell adhesion molecule CRISPR/Cas9 colorectal cancer translational models metastasis
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fgeed.2025.1679698/full
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