Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models

The tumoricidal efficiency of human CAR-T cells is generally evaluated using immune-deficient mouse models; however, due to their immune-incompetency and the species-specific reactivity of a target antigen, these models are problematic to imitate CAR-T-induced adverse effects in the clinic. Epitheli...

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Prif Awduron:	Diyuan Qin, Dan Li, Benxia Zhang, Yue Chen, Xuelian Liao, Xiaoyu Li, Peter B. Alexander, Yongsheng Wang, Qi-Jing Li
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Taylor & Francis Group 2020-01-01
Cyfres:	OncoImmunology
Pynciau:	epcam chimeric antigen receptor cancer immunotherapy immuno-oncology immunocompetent mouse model toxicities
Mynediad Ar-lein:	http://dx.doi.org/10.1080/2162402X.2020.1806009
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