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Destabilization of EpCAM dimer is associated with increased susceptibility towards cleavage by TACE

The cell-surface protein EpCAM is a carcinoma marker utilized in diagnostics and prognostics, and a promising therapeutic target. It is involved in nuclear signaling via regulated intramembrane proteolysis (RIP). Many aspects of this process are not fully understood, including the events at the mole...

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Autori principali: Tomaž Žagar, Miha Pavšič, Aljaž Gaber
Natura: Artigo
Lingua:Inglês
Pubblicazione: PeerJ Inc. 2021-05-01
Serie:PeerJ
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Accesso online:https://peerj.com/articles/11484.pdf
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