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Pan‐Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival

Abstract Genetic alterations in cancer cells trigger oncogenic transformation, a process largely mediated by the dysregulation of kinase and transcription factor (TF) activities. While the mutational profiles of thousands of tumours have been extensively characterised, the measurements of protein ac...

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Principais autores: Abel Sousa, Aurelien Dugourd, Danish Memon, Borgthor Petursson, Evangelia Petsalaki, Julio Saez‐Rodriguez, Pedro Beltrao
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2023-01-01
Serier:Molecular Systems Biology
Fag:
adaptation
cancer genomics
cell signalling
phosphoproteomics
protein activities
Online adgang:https://doi.org/10.15252/msb.202110631
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