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Portraying the dark side of endogenous IFN-λ for promoting cancer progression and immunoevasion in pan-cancer

Abstract Background IFN-λ has been shown to have a dual function in cancer, with its tumor-suppressive roles being well-established. However, the potential existence of a negative ‘‘tumor-promoting’’ effect of endogenous IFN-λ is still not fully understood. Methods We conducted a comprehensive revie...

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Principais autores: Zhen Zhen Wang, Xiao Ling Wen, Na Wang, Xu Hua Li, Yu Guo, Xu Zhu, Shu Heng Fu, Fei Fan Xiong, Jin Li, Limei Wang, Xiao Ling Gao, Hong Jiu Wang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-09-01
Serier:Journal of Translational Medicine
Fag:
Endogenous IFN-λ
Cancer-promoting
Multi-omics
Tumor microenviroment
Copy number variation
Online adgang:https://doi.org/10.1186/s12967-023-04453-4
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