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The effect of montelukast, a leukotriene receptor antagonist, on the acetic acid-induced model of colitis in rats: Involvement of NO-cGMP-KATP channels pathway

Inflammatory bowel disease is a chronic autoimmune disorder that may involve entire gastrointestinal tract. The leukotrienes have a role as mediators in the pathophysiology of colitis. Here, we investigated the effect of a leukotriene receptor antagonist, montelukast, and also the role of the NO-cGM...

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Principais autores: Behnam Ghorbanzadeh, Mohammad Amin Behmanesh, Roya Mahmoudinejad, Mehdi Zamaniyan, Shadi Ekhtiar, Yousef Paridar
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-09-01
coleção:Frontiers in Pharmacology
Assuntos:
montelucast
nitric oxide
cGMP
cyclic guanosine monophosphate
KATP channels
rats
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.1011141/full
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