Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti‐tumor efficacy

An immunosuppressive tumor microenvironment promotes tumor growth and is one of the main factors limiting the response to cancer immunotherapy. We have previously reported that inhibition of vacuolar protein sorting 34 (VPS34), a crucial lipid kinase in the autophagy/endosomal trafficking pathway, d...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Yasmin Yu, Madhumita Bogdan, Muhammad Zaeem Noman, Santiago Parpal, Elisabetta Bartolini, Kris Van Moer, Simone Caroline Kleinendorst, Kristine Bilgrav Saether, Lionel Trésaugues, Camilla Silvander, Johan Lindström, Jodi Simeon, Mary Jane Timson, Hikmat Al‐Hashimi, Bryan D. Smith, Daniel L. Flynn, Andrey Alexeyenko, Jenny Viklund, Martin Andersson, Jessica Martinsson, Katja Pokrovskaja Tamm, Angelo De Milito, Bassam Janji
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2024-08-01
coleção:	Molecular Oncology
Assuntos:	autophagy cancer immunotherapy interferons STING
Acesso em linha:	https://doi.org/10.1002/1878-0261.13619
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!