Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti‐tumor efficacy

An immunosuppressive tumor microenvironment promotes tumor growth and is one of the main factors limiting the response to cancer immunotherapy. We have previously reported that inhibition of vacuolar protein sorting 34 (VPS34), a crucial lipid kinase in the autophagy/endosomal trafficking pathway, d...

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मुख्य लेखकों:	Yasmin Yu, Madhumita Bogdan, Muhammad Zaeem Noman, Santiago Parpal, Elisabetta Bartolini, Kris Van Moer, Simone Caroline Kleinendorst, Kristine Bilgrav Saether, Lionel Trésaugues, Camilla Silvander, Johan Lindström, Jodi Simeon, Mary Jane Timson, Hikmat Al‐Hashimi, Bryan D. Smith, Daniel L. Flynn, Andrey Alexeyenko, Jenny Viklund, Martin Andersson, Jessica Martinsson, Katja Pokrovskaja Tamm, Angelo De Milito, Bassam Janji
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Wiley 2024-08-01
श्रृंखला:	Molecular Oncology
विषय:	autophagy cancer immunotherapy interferons STING
ऑनलाइन पहुंच:	https://doi.org/10.1002/1878-0261.13619
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