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The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors.

A somatic mutation in the FOXL2 gene is reported to be present in almost all (97%; 86/89) morphologically defined, adult-type, granulosa-cell tumors (A-GCTs). This FOXL2 c.402C>G mutation changes a highly conserved cysteine residue to a tryptophan (p.C134W). It was also found in a minority of other...

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Автори: Kasmintan A Schrader, Bella Gorbatcheva, Janine Senz, Alireza Heravi-Moussavi, Nataliya Melnyk, Clara Salamanca, Sarah Maines-Bandiera, Susanna L Cooke, Peter Leung, James D Brenton, C Blake Gilks, John Monahan, David G Huntsman
Формат: Artigo
Мова:Inglês
Опубліковано: Public Library of Science (PLoS) 2009-11-01
Серія:PLoS ONE
Онлайн доступ:http://europepmc.org/articles/PMC2777318?pdf=render
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