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Towards personalized vaccine repurposing for Alzheimer’s prevention: genotype-specific protective association of the shingles vaccine with odds of Alzheimer’s disease in participants of two large cohort studies

Abstract Background Our earlier study found that adult vaccination against shingles (herpes zoster infection caused by the reactivation of the varicella-zoster virus) was associated with significantly reduced risk of Alzheimer's disease (AD) later in life. Here, we investigated genotype-specific ass...

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Principais autores: Hongzhe Duan, Svetlana Ukraintseva, Rachel Holmes, Deqing Wu, Arseniy P. Yashkin, Igor Akushevich, Anatoliy Yashin, Konstantin Arbeev
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-02-01
Serier:BMC Neurology
Fag:
Alzheimer’s disease
Shingles vaccine
Herpes zoster
Health and Retirement Study
UK Biobank
Zostavax
Online adgang:https://doi.org/10.1186/s12883-026-04728-5
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