Pure and Confounded Effects of Causal SNPs on Longevity:Insights or Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures

This paper shows that the effects of causal SNPs on lifespan, estimated through GWAS, may be confounded and the genetic structure of the study population may be responsible for this effect. Simulation experiments show that levels of linkage disequilibrium (LD) and other parameters of the population...

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التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Anatoliy I Yashin, Ilya Zhbannikov, Liubov Arbeeva, Konstantin G. Arbeev, Deqing Wu, Mikhail Kovtun, Alexander M Kulminski, Igor Akushevich, Arseniy Yashkin, Irina Kulminskaya, Eric Stallard, Svetlana Ukraintseva
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2016-11-01
سلاسل:	Frontiers in Genetics
الموضوعات:	Linkage Disequilibrium population genetic structure population stratification mortality selection lack of replication causal SNP
الوصول للمادة أونلاين:	http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00188/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!