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NUP98 and RAE1 sustain progenitor function through HDAC-dependent chromatin targeting to escape from nucleolar localization

Abstract Self-renewing somatic tissues rely on progenitors to support the continuous tissue regeneration. The gene regulatory network maintaining progenitor function remains incompletely understood. Here we show that NUP98 and RAE1 are highly expressed in epidermal progenitors, forming a separate co...

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Principais autores: Amy E. Neely, Laura A. Blumensaadt, Patric J. Ho, Sarah M. Lloyd, Junghun Kweon, Ziyou Ren, Xiaomin Bao
格式: Artigo
語言:Inglês
出版: Nature Portfolio 2023-06-01
叢編:Communications Biology
在線閱讀:https://doi.org/10.1038/s42003-023-05043-2
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