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Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways

Abstract Phenotypic and functional changes in vascular smooth muscle cells (VSMCs) contribute significantly to cardiovascular diseases (CVD) but factors driving early adverse vascular changes are poorly understood. We report on novel and important roles for the Brn-3b/POU4F2 (Brn-3b) transcription f...

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主要な著者: Vaishaali Yogendran, Laura Mele, Oleksandra Prysyazhna, Vishwanie S. Budhram-Mahadeo
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2023-11-01
シリーズ:Cell Death and Disease
オンライン・アクセス:https://doi.org/10.1038/s41419-023-06306-w
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