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NK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotype

Pancreatic ductal adenocarcinoma (PDAC) is one of the most common tumor subtypes and remains associated with very poor survival. T cell infiltration into tumor tissue is associated with improved clinical outcome but little is known regarding the potential role of NK cells in disease control. Here we...

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Principais autores: Francesca Marcon, Jianmin Zuo, Hayden Pearce, Samantha Nicol, Sandra Margielewska-Davies, Mustafa Farhat, Brinder Mahon, Gary Middleton, Rachel Brown, Keith J. Roberts, Paul Moss
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2020-01-01
coleção:OncoImmunology
Assuntos:
pdac
nk cells
cancer immunology
immunomodulation
Acesso em linha:http://dx.doi.org/10.1080/2162402X.2020.1845424
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