PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse

IntroductionCirculating monocytes are main source for tumor-associated macrophages (TAMs) that control tumor growth, angiogenesis, metastasis and therapy resistance. We raised the questions how monocyte programming is affected by growing tumors localized in colon and rectal sections, and how treatme...

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Автори:	Irina Larionova, Marina Patysheva, Pavel Iamshchikov, Elena Kazakova, Anna Kazakova, Militsa Rakina, Evgeniya Grigoryeva, Anna Tarasova, Sergei Afanasiev, Natalia Bezgodova, Artem Kiselev, Alexey Dobrodeev, Dmitriy Kostromitskiy, Nadezhda Cherdyntseva, Julia Kzhyshkowska
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2023-01-01
Серія:	Frontiers in Immunology
Предмети:	monocyte PFKFB3 colorectal cancer tumor-associated macrophage transcriptome GeoMx DSP
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1080501/full
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