Tumor-associated macrophages respond to chemotherapy by detrimental transcriptional reprogramming and suppressing stabilin-1 mediated clearance of EGF

IntroductionTumor resistance to chemotherapy and metastatic relapse account for more than 90% of cancer specific mortality. Tumor-associated macrophages (TAMs) can process chemotherapeutic agents and impair their action. Little is known about the direct effects of chemotherapy on TAMs.MethodsThe eff...

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主要な著者:	Irina Larionova, Artem Kiselev, Elena Kazakova, Tengfei Liu, Marina Patysheva, Pavel Iamshchikov, Quan Liu, Dieuwertje M. Mossel, Vladimir Riabov, Militsa Rakina, Alexey Sergushichev, Natalia Bezgodova, Sergei Vtorushin, Nikolai Litviakov, Evgeny Denisov, Philipp Koshkin, Denis Pyankov, Matvei Tsyganov, Marina Ibragimova, Nadezhda Cherdyntseva, Julia Kzhyshkowska
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2023-03-01
シリーズ:	Frontiers in Immunology
主題:	tumor-associated macrophage (TAM) cisplatin breast cancer stabilin-1 EGF endocytosis
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1000497/full
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