Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

ABSTRACT Non‐NF2 Schwannomatosis (SWN) is a genetic disorder characterized by multiple non‐malignant schwannomas growing on the spine and peripheral nerves. Patients with SWN overwhelmingly present with intractable chronic pain. There are no FDA‐approved drugs to halt tumor growth or alleviate pain....

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Principais autores:	Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2026-05-01
Series:	Advanced Science
Assuntos:	anti‐IL‐6 EGF‐R inhibitor pain patient‐derived orthotopic model Schwannoma‐neuron‐macrophage cross talk schwannomatosis
Acceso en liña:	https://doi.org/10.1002/advs.202515597
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