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Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

ABSTRACT Non‐NF2 Schwannomatosis (SWN) is a genetic disorder characterized by multiple non‐malignant schwannomas growing on the spine and peripheral nerves. Patients with SWN overwhelmingly present with intractable chronic pain. There are no FDA‐approved drugs to halt tumor growth or alleviate pain....

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Main Authors: Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu
Format: Artigo
Language:Inglês
Published: Wiley 2026-05-01
Series:Advanced Science
Subjects:
anti‐IL‐6
EGF‐R inhibitor
pain
patient‐derived orthotopic model
Schwannoma‐neuron‐macrophage cross talk
schwannomatosis
Online Access:https://doi.org/10.1002/advs.202515597
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