Simvastatin Resistance of <i>Leishmania amazonensis</i> Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors

The sterol biosynthesis pathway of <i>Leishmania</i> spp. is used as a pharmacological target; however, available information about the mechanisms of the regulation and remodeling of sterol-related genes is scarce. The present study investigated compensatory mechanisms of the sterol biosynthesis pat...

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Autores principales:	Thais Tenorio Soares Fujii, Pollyanna Stephanie Gomes, Rubens Lima do Monte-Neto, Daniel Claudio de Oliveira Gomes, Marc Ouellette, Eduardo Caio Torres-Santos, Valter Viana Andrade-Neto, Herbert Leonel de Matos Guedes
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2022-02-01
Colección:	Microorganisms
Materias:	<i>Leishmania amazonensis</i> sterol pathway HMG-CoA reductase simvastatin resistance pharmacological target serine proteases
Acceso en línea:	https://www.mdpi.com/2076-2607/10/2/398
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