A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity

Emerging evidence has suggested that aldosterone has direct deleterious effects on the kidney independently of its hemodynamic effects. However, the detailed mechanisms of these direct effects remain to be elucidated. We have previously reported that camostat mesilate (CM), a synthetic serine protea...

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Auteurs principaux:	Yutaka Kakizoe, Yoshikazu Miyasato, Tomoaki Onoue, Terumasa Nakagawa, Manabu Hayata, Kohei Uchimura, Jun Morinaga, Teruhiko Mizumoto, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Kimio Tomita, Masashi Mukoyama, Kenichiro Kitamura
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2016-10-01
Collection:	Journal of Pharmacological Sciences
Sujets:	Aldosterone Kidney injury Serine protease Plasmin Serine protease inhibitor
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S134786131630130X
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