Camostat mesilate, a serine protease inhibitor, exerts aquaretic effects and decreases urinary exosomal AQP2 levels

Serine proteases (SPs) play physiological roles in the kidney. We previously reported that a synthetic SP inhibitor, camostat mesilate (CM), suppressed sodium reabsorption in the renal tubule and showed natriuretic effects in aldosterone-infused rats. Here, we aimed to explore novel physiological ro...

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Auteurs principaux:	Yutaka Kakizoe, Terumasa Nakagawa, Yasunobu Iwata, Qinyuan Deng, Masataka Adachi, Yoshikazu Miyasato, Miyuki Nakagawa, Yu Nagayoshi, Kayo Nishiguchi, Yuki Narita, Yuichiro Izumi, Takashige Kuwabara, Kimio Tomita, Kenichiro Kitamura, Masashi Mukoyama
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2022-12-01
Collection:	Journal of Pharmacological Sciences
Sujets:	Serine protease Camostat mesilate Water diuresis AQP2 Exosome
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S1347861322000706
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