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Effects of a Serine Protease Inhibitor N-<i>p</i>-Tosyl-L-phenylalanine Chloromethyl Ketone (TPCK) on <i>Leishmania amazonensis</i> and <i>Leishmania infantum</i>

Studies have previously demonstrated the importance of serine proteases in <i>Leishmania</i>. A well-known serine protease inhibitor, TPCK, was used in the present study to evaluate its in vitro and in vivo antileishmanial effects and determine its mechanism of action. Despite slight toxicity agains...

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Principais autores: Patrícia de A. Machado, Pollyanna S. Gomes, Monique P. D. Carneiro, Victor Midlej, Elaine S. Coimbra, Herbert L. de Matos Guedes
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2022-06-01
סדרה:Pharmaceutics
נושאים:
serine proteases
TPCK
leishmaniasis
<i>Leishmania amazonensis</i>
<i>Leishmania infantum</i>
גישה מקוונת:https://www.mdpi.com/1999-4923/14/7/1373
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