Effects of a Serine Protease Inhibitor N-<i>p</i>-Tosyl-L-phenylalanine Chloromethyl Ketone (TPCK) on <i>Leishmania amazonensis</i> and <i>Leishmania infantum</i>

Studies have previously demonstrated the importance of serine proteases in <i>Leishmania</i>. A well-known serine protease inhibitor, TPCK, was used in the present study to evaluate its in vitro and in vivo antileishmanial effects and determine its mechanism of action. Despite slight toxicity agains...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Patrícia de A. Machado, Pollyanna S. Gomes, Monique P. D. Carneiro, Victor Midlej, Elaine S. Coimbra, Herbert L. de Matos Guedes
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-06-01
coleção:	Pharmaceutics
Assuntos:	serine proteases TPCK leishmaniasis <i>Leishmania amazonensis</i> <i>Leishmania infantum</i>
Acesso em linha:	https://www.mdpi.com/1999-4923/14/7/1373
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!