MLN4924 inhibits macrophage foam cell formation by enhancing autophagy and regulating metabolic phenotype
Abstract Background MLN4924 is a novel small molecule inhibitor of neddylation. During clinical trials, it has demonstrated promising therapeutic efficacy in hematological malignancies, lung cancer, and colon cancer. MLN4924 possesses anti-inflammatory properties and promotes cardiomyocyte autophagy...
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| Автори: | , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
BMC
2025-10-01
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| Серія: | Lipids in Health and Disease |
| Предмети: | |
| Онлайн доступ: | https://doi.org/10.1186/s12944-025-02683-7 |
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