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Integrated analysis reveals the regulatory mechanism of the neddylation inhibitor MLN4924 on the metabolic dysregulation in rabbit granulosa cells

Abstract Background Neddylation, an important post-translational modification (PTM) of proteins, plays a crucial role in follicular development. MLN4924 is a small-molecule inhibitor of the neddylation-activating enzyme (NAE) that regulates various biological processes. However, the regulatory mecha...

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Hlavní autoři: Mengjuan Chen, Yuqing Liu, Mingzhong Zuo, Meina Zhang, Zhitong Wang, Xin Li, Dongdong Yuan, Huifen Xu, Guangqing Yu, Ming Li
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2024-03-01
Edice:BMC Genomics
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On-line přístup:https://doi.org/10.1186/s12864-024-10118-3
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