Application of different types of CRISPR/Cas-based systems in bacteria

Abstract As important genome editing tools, CRISPR/Cas systems, especially those based on type II Cas9 and type V Cas12a, are widely used in genetic and metabolic engineering of bacteria. However, the intrinsic toxicity of Cas9 and Cas12a-mediated CRISPR/Cas tools can lead to cell death in some stra...

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Principais autores:	Zhenquan Liu, Huina Dong, Yali Cui, Lina Cong, Dawei Zhang
格式:	Artigo
语言:	Inglês
出版:	BMC 2020-09-01
丛编:	Microbial Cell Factories
主题:	CRISPR/Cas system Genome editing Bacteria
在线阅读:	http://link.springer.com/article/10.1186/s12934-020-01431-z
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