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Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes

564Igi mice have knocked-in immunoglobulin (Ig) heavy (H) and light (L) chain genes that encode an autoantibody recognizing RNA. Previously, we showed that these mice produce pathogenic IgG autoantibodies when activation-induced deaminase (AID) is expressed in pre-B and immature B cells but not when...

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Sábháilte in:
Príomhchruthaitheoirí: Gabrielle McDonald, Carlos O. Medina, Monika Pilichowska, John F. Kearney, Reiko Shinkura, Erik Selsing, Henry H. Wortis, Tasuku Honjo, Thereza Imanishi-Kari
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Frontiers Media S.A. 2017-09-01
Sraith:Frontiers in Immunology
Ábhair:
activation-induced cytidine deaminase
somatic hypermutation
class switch recombination
systemic lupus erythematosus
autoantibodies
pathogenic antibodies
Rochtain ar líne:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01094/full
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