T Cell Receptor Alpha Chain Genes in the Teleost Ballan Wrasse (Labrus bergylta) Are Subjected to Somatic Hypermutation

Previously, somatic hypermutation (SHM) was considered to be exclusively associated with affinity maturation of antibodies, although it also occurred in T cells under certain conditions. More recently, it has been shown that SHM generates diversity in the variable domain of T cell receptor (TCR) in...

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Principais autores:	Sumaira Bilal, Kai Kristoffer Lie, Øystein Sæle, Ivar Hordvik
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2018-05-01
Series:	Frontiers in Immunology
Assuntos:	T cell receptor ballan wrasse TCRα polymorphism somatic hypermutation activation-induced cytidine deaminase motif
Acceso en liña:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01101/full
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