Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

ABSTRACT The use of chimeric antigen receptor (CAR) T‐cell therapy for T‐cell malignancies is limited by fratricide, antigen‐escape, lack of functional endurance and adverse events such as multilineage cytopenia. To address these limitations, we developed a simple single‐step CD7‐depletion process f...

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Bibliografski detalji

Glavni autori:	Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2026-06-01
Serija:	Advanced Science
Teme:	cancer immunotherapy CAR T‐cell therapy dual‐targeted therapy hematological disease t‐cell malignancies
Online pristup:	https://doi.org/10.1002/advs.202521443
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