Evaluating the current state of Mendelian randomization studies: a protocol for a systematic review on methodological and clinical aspects using neurodegenerative disorders as outcome

Abstract Background Mendelian randomization (MR) is fast becoming a popular method to judge causality from routinely conducted observational studies. However, stringent underlying statistical assumptions, missing biological information, and high sample size requirement might make it prone to misuse....

Descrizione completa

Dettagli Bibliografici

Autori principali:	Sandeep Grover, Fabiola Del Greco M., Inke R. König
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2018-09-01
Serie:	Systematic Reviews
Soggetti:	Mendelian randomization Instrumental variable Observational epidemiology Genome-wide association study Summary data Pleiotropy
Accesso online:	http://link.springer.com/article/10.1186/s13643-018-0809-3
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!